(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇
坎格列净(canagliflozin)
CAS: 842133-18-0;928672-86-0
化学式: 2(C24H25FO5S).H2O
| 中文名 | 坎格列净 |
| 英文名 | canagliflozin |
| 别名 | 坎格列净 卡格列净 卡格列净半水 卡格列净半水物 坎格列嗪半水物 卡格列净无水物 卡格列净半水合物 坎格列净(半水) 坎格列净半水合物 坎格列净半水化合物 坎格列净半水合物(坎格列净) (1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇 |
| 英文别名 | Cageline canagliflozin Cagliflozin heMihydrate Canagliflozin heMihydrate Canagliflozin heMihydrates 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate |
| CAS | 842133-18-0 928672-86-0 |
| EINECS | 202-303-5 |
| 化学式 | 2(C24H25FO5S).H2O |
| 分子量 | 462.53 |
| 密度 | 1.4±0.1 g/cm3 |
| 熔点 | 94-96°C |
| 沸点 | 642.9±55.0 °C at 760 mmHg |
| 闪点 | 342.6±31.5 °C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 存储条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| MDL号 | MFCD18251436 |
| 体外研究 | Canagliflozin inhibits Na + -dependent 14 C-AMG uptake in CHO-hSGLT2 cells, with an IC 50 of 4.4±1.2 nM. Similar IC 50 values are obtained in CHO-rSGLT2 and CHO-mSGLT2 cells (IC 50 = 3.7 and 2.0 nM for rat and mouse SGLT2, respectively). Canagliflozin inhibits 14 C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC 50 of 684±159 nM and >1,000 nM, respectively. |
| 体内研究 | Canagliflozin (30 mg/kg treatment for 4 weeks) reduced blood glucose (BG) levels, respiratory exchange ratio, and body weight gain in DIO mice. Canagliflozin (3 mg/kg for 3 weeks) increases urinary glucose excretion (UGE) with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight In ZF rats. Animal Model: Diet-induced obese, insulin resistantmice (DIO) Mice Dosage: 30 mg/kg Administration: Oral gavage; daily; 4 weeks Result: Reduced BG levels, respiratory exchange ratio, and body weight gain. Animal Model: Male Zucker fatty (ZF) obese, insulin resistant rats Dosage: 3 mg/kg Administration: Oral gavage; daily; 3 weeks Result: UGE was increased with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight. |
(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇 - 介绍
Canagliflozin inhibits Na+- dependent 14C-AMG uptake in a concentration-dependent fashion. It is a novel C-glucoside with thiophene ring.
最后更新：2022-10-16 17:29:19
![(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇](http://res.chembk.com/assets/images/structure/311111.gif)
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产品名: Canagliflozin 去供应商网站查看 询盘CAS: 842133-18-0
产地: 中国上海
包装: 10mg
规格: ≥98%
价格: 89.00
库存: 现货
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产品描述: 中文名：Canagliflozin 英文名:Canagliflozin CAS:842133-18-0 规格:≥98% 产地:中国上海
提供多种规格现货供应
产品名: Canagliflozin 去供应商网站查看 询盘CAS: 842133-18-0
产地: 上海
规格: HPLC≥99%
价格: 20mg 600
库存: 现货
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产品描述: Canagliflozin HPLC≥99% 源叶 货号：B27238
提供多种规格现货供应
产品名: Canagliflozin 去供应商网站查看 询盘CAS: 842133-18-0
产地: 中国上海
包装: 10mg
规格: ≥98%
价格: 89.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Canagliflozin 英文名:Canagliflozin CAS:842133-18-0 规格:≥98% 产地:中国上海
提供多种规格现货供应
产品名: Canagliflozin 去供应商网站查看 询盘CAS: 842133-18-0
产地: 上海
规格: HPLC≥99%
价格: 20mg 600
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Canagliflozin HPLC≥99% 源叶 货号：B27238
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